The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel

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The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel: an experimental study in rats.

Conventional non-steroidal anti-inflammatory drugs (NSAIDs) and newer specific cyclo-oxygenase-2 (cox-2) inhibitors are commonly used in musculoskeletal trauma and orthopaedic surgery to reduce the inflammatory response and pain. These drugs have been reported to impair bone metabolism. In reconstruction of the anterior cruciate ligament the hamstring tendons are mainly used as the graft of cho...

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The Effect of Bone Marrow Graft on Bone Healing: A Radiological and Biomechanical Study

Background: There are multiple methods for acceleration of bone healing. Bone marrow has been shown to contain osteoprogenitor cells. Objective: To determine the effect of percutaneous bone marrow injection on bone healing. Methods: 15 mature, 2-kg-weighing white New Zealand rabbits from both sexes were randomized into 3 groups: Group I: Only osteotomy of right radius was performed and a 5 mm b...

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Bioengineered periosteal progenitor cell sheets to enhance tendon-bone healing in a bone tunnel.

BACKGROUND Tendon-bone tunnel healing is crucial for long term success in anterior cruciate ligament (ACL) reconstruction. The periosteum contains osteochondral progenitor cells that can differentiate into osteoblasts and chondroblasts during tendon-bone healing. We developed a scaffold-free method using polymerized fibrin-coated dishes to make functional periosteal progenitor cell (PPC) sheets...

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Effect of bone morphogenetic protein 2 on tendon-to-bone healing in a canine flexor tendon model.

Tendon-to-bone healing is typically poor, with a high rate of repair-site rupture. Bone loss after tendon-to-bone repair may contribute to poor outcomes. Therefore, we hypothesized that the local application of the osteogenic growth factor bone morphogenetic protein 2 (BMP-2) would promote bone formation, leading to improved repair-site mechanical properties. Intrasynovial canine flexor tendons...

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Effect of a static magnetic field on bone healing in the dog: radiographic and histopathological studies

Although the promotional effects on bone healing of pulsed electromagnetic fields (PEMF) have beenwell demonstrated, the effects of static magnetic fields (SMF) remained unclear. In this study, effects of acustom-made magnetic wrap on radiographic and histopathological aspects of bone healing using a canineunstable osteotomy gap model were investigated. After an osteotomy of the midshaft radius...

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ژورنال

عنوان ژورنال: The Journal of Bone and Joint Surgery. British volume

سال: 2009

ISSN: 0301-620X,2044-5377

DOI: 10.1302/0301-620x.91b2.21471